Rat maternal diabetes impairs pancreatic -cell function in the offspring

Han J, Xu J, Long YS, Epstein PN, Liu YQ. Rat maternal diabetes impairs pancreatic -cell function in the offspring. Am J Physiol Endocrinol Metab 293: E228–E236, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00479.2006.—It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechanisms for these effects on the offspring are not well understood, and little information is available to reveal the mechanisms. We studied the effect of maternal diabetes on -cell function in the offspring of streptozotocin (STZ)-induced diabetic rat mothers (STZ-offspring). STZ-offspring did not become glucose intolerant up to 15 wk of age. At this age, however, insulin secretion was significantly impaired, as measured by in vivo and in vitro studies. Consistent with these changes, islet glucose metabolism and some important glucose metabolic enzyme activities were reduced. No significant changes were found in islet morphological analysis. These data indicate that -cell function is impaired in adult STZ-offspring; these changes may contribute to the development of type 2 diabetes mellitus in adulthood.